HRMS

Q: How is HRMS different from conventional MS?

HRMS provides much higher mass accuracy and resolution , enabling confident molecular formula determination and differentiation of closely related compounds.

Q: Is HRMS suitable for unknown screening?

Yes. HRMS is one of the most powerful tools for non-target screening and unknown identification .

What Is HRMS?

HRMS measures the mass-to-charge ratio of ions with very high mass accuracy and resolution, allowing determination of exact molecular weights and elemental compositions. This capability makes HRMS especially powerful for:

unknown compound identification
non-target screening
differentiation of isomers and closely related species
trace-level impurity detection

HRMS is commonly integrated with separation techniques such as chromatography to analyze complex samples.

What HRMS Measures

HRMS can provide:

Accurate molecular mass
Elemental composition (molecular formula)
Isotopic pattern information
Trace-level impurity detection
Degradation and by-product profiling
Comparison of complex chemical fingerprints

High mass accuracy significantly increases confidence in compound identification.

Why Use HRMS?

HRMS is chosen when standard MS techniques are not sufficient. It helps answer questions such as:

What is the exact identity of an unknown compound?
Are there trace impurities not resolved by conventional MS?
Do two materials differ at the molecular level?
Are degradation products present at very low levels?
What by-products are formed during processing or aging?

HRMS is ideal for forensic-level chemical analysis and high-confidence decision-making.

Typical Application Scenarios

Unknown Identification & Non-Target Screening

Identification of unexpected compounds
Forensic-level contamination investigations
Root-cause analysis of unexplained failures

Impurity & Trace Analysis

Detection of ultra-low-level impurities
High-purity material qualification
Supplier and batch comparison

Deformulation & Reverse Engineering

Identification of formulation components
Competitive product analysis
Characterization of proprietary additives

Materials & Product Development

Profiling of reaction by-products
Stability and degradation pathway studies
Optimization of formulations and processes

Failure Analysis

Investigation of chemical changes in failed materials
Comparison of “good vs. failed” samples
Identification of chemical contributors to performance loss

Sample Types

HRMS can be applied to:

polymers and advanced materials
chemicals and specialty compounds
coatings, adhesives, and sealants
consumer and industrial products

Depending on the objective, HRMS may be combined with appropriate separation or ionization strategies to maximize identification confidence.

What You Will Receive

Each HRMS project is delivered with a high-confidence, structured report suitable for technical and strategic decision-making. A typical deliverable includes:

project objective and sample description
analytical approach and acquisition conditions
accurate-mass spectra and molecular formula assignments
identification of unknowns with confidence assessment
comparison between samples or conditions
interpretation of findings and potential sources
recommendations for mitigation, optimization, or follow-up testing

Why Choose Xinbodi for HRMS?

Advanced high-resolution mass spectrometry capability
Expertise in unknown and trace-level compound identification
Accurate-mass interpretation and expert data analysis
Flexible strategies for complex material systems
Clear conclusions beyond raw spectral data
Strict confidentiality for proprietary formulations and IP-sensitive projects